Accurate Inclusion Mass Screening

Accurate inclusion mass screening: a bridge from unbiased discovery to targeted assay development for biomarker verification.

Verification of candidate biomarker proteins in blood is typically done using multiple reaction monitoring (MRM) of peptides by LC-MS/MS on triple quadrupole MS systems. MRM assay development for each protein requires significant time and cost, much of which is likely to be of little value if the candidate biomarker is below the detection limit in blood or a false positive in the original disco...

Accurate Mass Screening Of Pharmaceuticals In Water And Sediment By Uhplc-Orbitrap Mass Spectrometry

The extended use of pharmaceuticals is a potential contamination source of surface water, groundwater, sea water and soils. Pharmaceuticals are among the most prescribed pharmaceutically active substances throughout the world. Their presence and persistence in environmental matrices and the toxicity posed by them as well, according to the first studies carried out, indicate that environmental m...

accurate-mass spectra

High-Resolution Accurate-Mass (HRAM) Phthalate Screening using Direct Analysis in Real Time (DART) Ambient Ionization

Screening and Confirmation of Anabolic Steroids Using Accurate Mass LC/MS Application

The use of the Agilent LC/MSD TOF, an orthogonal-axis time-of-flight (oa-TOF) mass spectrometer, equipped with an atmospheric pressure chemical ionization (APCI) source, is described for the analysis of four anabolic steroids and one internal standard, in urine extracts at a 1–2 ng/mL concentration. The high degree of mass accuracy (<3 ppm) of the TOF instrument allows for both excellent confir...